The ATLAS (Altered TCR Ligand Affinities and Structures) database is a manually curated repository containing the binding affinities for wild-type and mutant T cell receptors (TCRs) and their antigens, peptides presented by the major histocompatibility complex (MHC). The database links experimentally measured binding affinities with the corresponding three dimensional structures for TCR-pMHC complexes.
The user can browse and search affinities, structures, and experimental details for TCRs, peptides, and MHCs of interest. We aim to facilitate the development of next-generation protein design algorithms targeting the TCR-pMHC interface. With this in mind, ATLAS is designed to be easily parsed using modeling software that builds protein structures for training and testing. All collections of structures, affinities, and statistics in ATLAS are available for download.